Is There Relationship Between Thyroid Volume, Hyperparathyroidism and Cardiovascular Risk Factors in Patients Under Hemodialysis?

Author(s): Ali Gurel, Emin Murat Akbas, Hunkar Aggul, Kursat Kaya

Background: Thyroid dysfunction and hyperparathyroidism are common in with chronic kidney disease (CKD) and under dialysis. It is known that they increase the risk of cardiovascular (CV) diseases in this population.

Objectives: In this study, we aimed to investigate the relationship between thyroid volume, hyperparathyroidism (HPTH), atherogenic index of plasma (AIP), carotis intima-media thickness (CIMT) and uric acid (UA) in hemodialysis (HD) patients.

Methodology: Hemodialysis patients without thyroid dysfunction were divided into three groups as; low (<13.6 pg/mL), target (13.6-61.2 pg/mL) and high (> 61.2 pg/mL) parathyroid hormone (PTH) levels continuing for at least 6 months. Routine laboratory tests, PTH, lipid profile, high sensitive CRP (hs-CRP), TSH, T4, T3, glucose, UA, insulin, C-peptide, AIP, thyroid ultrasonography performed and CIMT were evaluated and recorded.

Results: Total thyroid volume was 21.64 ± 1.83, 15.01 ± 1.60, 19.52 ± 1.41 mL respectively in males, females and whole group. Total thyroid volume, AIP, hs-CRP, UA, bilateral CIMT were all lower in low PTH group in comparison with other groups, but statistically significant only for hs-CRP levels. There was positive correlation between total thyroid volume and bilateral CIMT, hs-CRP; and negative correlation between Kt/V and thyroid volume. Conclusion: In HD patients; thyroid volume may be an indicator of CV risk in harmony with other risk factors.

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