Headway of miR200 Family as a Novel Biomarker in Head and Neck Cancers

Author(s): Shivani Kadarla, Rajesh Kumar Galimudi, Surekha Rani Hanumanth, Srimanth Kumar Barigela, Durga NeeharikaRani, Madhavi Jangala, Pardha P Reddy, Raja Meghanadh Koralla

Head and neck squamous cell carcinoma (HNSCC) a varied disease, comprising variety of tumors that grow on the mucosa of the aerodigestive tract and arise in the regions of hypopharynx, oropharynx, salivary gland, oral cavity, nasopharynx, or larynx. About 650,000 new cases of HNSCC are diagnosed annually all over the world, with a ratio comprising of 3:1 between men and women. The role of microRNAs (miRNAs) in cancer development was known to be as oncogene or tumor suppressor. One of the miRNA family, miR-200 was mainly characterized as a tumor suppressor in head and neck cancers, it is composed of five highly conserved miRNAs, including miR-141, miR-200a/200b/200c, and miR- 429. Alterations observed in miR200 family genes concerning HNSCC can be well explained by epigenetic modifications like miRNA methylation and expression, In-silico analysis to facilitate the development of targeted therapies, leading to improved patient outcomes.