Assessment of Nutritional Status and Its Association with Inflammation among Patients on Continuous Ambulatory Peritoneal Dialysis

Author(s): Mekhola MH, Chowdhury MAA, Alam KS, Saha S, Hossain MS, Mahjabeen S, Samdani A, Azim N, Rahman AKMS

Continuous ambulatory peritoneal dialysis (CAPD) is one of the therapeutic options in end stage renal disease (ESRD). Malnutrition is prevalent among patients on CAPD. This study was aimed to assess the nutritional status and its association with inflammation among patients on CAPD. This study was conducted at the Department of Nephrology, National Institute of Kidney Diseases and Urology (NIKDU), Dhaka, Bangladesh from July 2018 to June 2019. A total of sixty-nine (69) ESRD patients on CAPD were enrolled. Demographic profile, clinical history and nutritional status of each study patient were recorded. All relevant investigations were done accordingly. Their 24 hours urine and 24 hours effluent were collected for urea and creatinine levels to detect- adequacy of dialysis, residual renal function and normalized protein catabolic rate (nPCR). Malnutrition inflammation score (MIS) was performed following standard procedure. In this study, malnutrition inflammation score (MIS) is higher among CAPD patients. It was observed that, 78.3% patients were malnourished. Serum albumin, serum pre-albumin, total iron binding capacity (TIBC) and body mass index (BMI) showed significant negative correlation with MIS; however high sensitive C-reactive protein (hsCRP) showed positive correlation with MIS. This study concluded that, malnutrition inflammation score (MIS) is related to inflammation in continuous ambulatory peritoneal dialysis (CAPD) patients.

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