Advances in Extracellular Vesicles in the Treatment of Osteosarcoma

Author(s): Zhefei Du, Lixin Xie, Daihan Xie, Kesheng Wang, Qiuxia Peng, Chao Fang

Osteosarcoma, a prevalent primary malignant bone tumor, presents a pressing challenge in terms of improving patient prognosis effectively. Extracellular vesicles, encompassing vesicular structure with a bilayered biomembrane released by cells, have been shown to play a significant role in the pathogenesis and progression of osteosarcoma. This mini-review provides an overview of the fundamental biological characteristics of extracellular vesicles and their therapeutic implications in osteosarcoma. Furthermore, it presents an outlook on the current limitations of extracellular vesicles and their potential future applications.