Adult Granulosa Cell Tumor of the Ovary: Initial Evaluation and Current Treatment Paradigm

Author(s): Melissa Hodeib, Ilene Tsui, Abed Sinno, Nisha Bansal and Joshua G. Cohen

Adult granulosa cell tumor (AGCT) is a sex cord stromal tumor (SCST) which constitutes 2-5% of all ovarian cancers. Initial treatment of early stage disease includes primary surgical resection with or without adjuvant treatment. Late stage disease and recurrent disease management involves multimodality treatment with surgical resection as the mainstay. Given the rarity of this tumor and its relative chemoresistance, future study is needed to better guide adjuvant treatment and individualize therapy for patients. Further evaluation of diagnostic and potential therapeutic implications involving FOXL2 mutations in AGCT is warranted.

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