Unusual (Achromobacter Xylosoxidans) Germ in Blood Culture of Newborn

Article Information

Nahid Mahir1, 2*, Fatiha Bennaoui1, 2, Fatimatoezzohra El Hanafi1, 2, Nabila Soraa3,  Nadia Elidrissi Sletine1, 2, Fadl Mrabih Rabou Maoulainine1, 2

1Department of Neonatal Intensive Care, Mohammed VI University Hospital and Research, Marrakech,  Morocco

2Child Health and Development Research Laboratory, Marrakech school of medicine Cadi Ayyad University, Marrakech, Morocco

3Department of Microbiology, Mohammed VI University Hospital and Research, Marrakech, Morocco

*Corresponding Author: Nahid Mahir, Department of Neonatal Intensive Care, Mohammed VI University Hospital and Research, Child Health and Development Research Laboratory, Marrakech school of medicine Cadi Ayyad University, Marrakech, Morocco

Received: 27 March 2021; Accepted: 06 April 2021; Published: 20 May 2021


Nahid Mahir, Fatiha Bennaoui, Fatimatoezzohra El Hanafi, Nabila Soraa, Nadia Elidrissi Sletine, Fadl Mrabih Rabou Maoulainine. Unusual (Achromobacter Xylosoxidans) Germ in Blood Culture of Newborn. Journal of Pediatrics, Perinatology and Child Health 5 (2021): 099-102.

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Introduction: Achromobacter xylosoxidans is an organism causes opportunistic infections; is a catalyst- and oxidase-positive, motile, gram-negative rod that oxidizes xylose and glucose. The bacteria will be confused with Pseudomonas species.

Objective: intravenous infection at the first time it is determined in neonatal hospitalization.

Observation: We will report the observation of a newborn baby who died due to a septicemia a Achromobacter xylosoxydans who resisted the imipenemes normally sensitive toy for the 1st time encountered in the neonatal intensive care unit CHU MOHAMED VI MARRAKECH MORROCO which never found in our hospital and which may be the declaration 'a new epidemic.

Conclusion: Axylosoxidans causes opportunistic infections that can be fatal in newborn with bacteremia The organism probably exists in a water environment and can be confused with Pseudomonas species and it's never found In our CHU.


Achromobacter Xylosoxidans, Nosocomial, Unusual Infection

Achromobacter Xylosoxidans articles; Nosoco-mial articles; Unusual Infection articles

Article Details

1. Introduction

Nosocomial infection is a major health problem. The most germs isolated in Moroccan’s hospitals are klebseila pneumonia and pseudomonas aerogenosa, the emergence of new strains carried away is still in question, Achromobacter xylosoxidans, is an aerobic, gram-negative rod, is rarely isolated from clinical material It was never found in the neonatal department of the CHU Marrakech. It ‘is the first time that is isolated in our CHU. The purpose of this report is to describe our experience with Axylosoxidans isolated from blood culture in a newborn.

2. Observation

A female neonate of 30 weeks gestational age was born to a 28-year-old woman, primiparous primagest. The mother presented in early labor with presumed severe preeclampsia, hi gave birth by caesarean to newborn that had a 1300 and has presented since birth a respiratory distress rated 5/10 according to the score of  Silverman, with Apgar scores of 7 at 1 minute and 8 at 5 minutes,  because of hyaline membrane disease, for that reason  it was surfaced. On the second day of life, she presented with persistent hyperthermia T° 38°C and the  HERO score was of 3, requiring work-up a blood test objectified white blood cells 14790/mm3, including 64% neutrophils and 26% lymphocytes, a reactive protein a 1,61 rag/l, in the fourth day the blood culture was positive to achromobacter xylosoxydan, resistant to cefotaxime and aminoglycosides, ticarcillin and sensitive to piperacillin and imipenem. Initial antibiotic therapy combined C3Gs and gentamicin, then adapted to tiename and amikacin. The patient received 5 days of intravenous treatment, The infant's course was complicated, and her condition continued to deteriorate and he developed hypotension and bradycardia requiring a short epinephrine infusion. The blood culture becomes sterile after 5 days; The child required intubation for decreased heart rate and absence of spontaneous respiration. Despite maximal support, the infant died after five day by septic shock.

3. Discussion

Achromobacter xylosoxidans is a non-fermentative Gram-negative bacillus emerging in cystic fibrosis, it is a bacterium described for the first time in 1971, isolated in medical centers in Latin America during the SENTRY program 1997-2002 [1]. It's an uncommon neonatal pathogen. The genus Achromobacter was firstly described in 1891 by Eisenberg, in 1923 by Bergey [2], and then in 1971 in an otorrhea sample [3], this genus belongs to the Alcaligenaceae family. Rare studies have clarified the natural resistance phenotype [4]. Until 1981 A. xylosoxidans was declared as an opportunistic pathogen according to Yabuuchi and Yano in the International Journal of Systematic Bacteriology; who found the germ in various pathological samples (blood, cerebrospinal fluid, pleural fluid, peritoneal fluid, urine, stool, ear pus, pharynx, eyes and various pus) [5]. However, the “pathogenic” nature of these bacteria remains controversial. However, it has been shown that A. xylosoxidans was responsible for nosocomial infections in immunocompromised patients [6].Different studies have described A. xylosoxidans in bacteremia [7]; Aisenberg et al. [2] and endocarditis [8, 9] as well as chronic purulent otitis [10], keratitis [1], pneumopathies [6] or urinary tract infections [12]. Cases of meningitis [8, 13, 14] postoperative endophthalmitis [15], and osteomyelitis [16, 17]. However, it rarely isolated  in neonatal hospitalization, so between 2009- 2010 a Turkish study described an outbreak of Achromobacter xylosoxidans in a neonatal intensive care unit. Is that affected 22 newborn and it was fatal in 3 patients [19]. In 2013, a few rare studies which described the virulence of the germs among newborns [18]. However neonatological infections with achromobacter xylosoxydans are rarely detected, in our context it was the 1st time that this germ has been encountered in blood cultures of newborns.

4. Conclusion

A,xylosoxidans causes opportunistic infections that can be fatal in newborn with bacteremia  The organism probably exists in a water environment and can be confused with Pseudomonas species. The antimicrobial susceptibility profile for each case should be taken into account in determining treatment. The virulence and clinical course under treatment is not well understood in our context. Further studies are needed to assess the importance of the different sources of contamination in hospital units.


  1. Gales AC, Jones RN, Andrade SS, et al. Antimicrobial susceptibility patterns of unusual nonfermentative Gram-negative bacilli isolated from Latin America: report from the SENTRY Antimicrobial Surveillance Program(1997–2002). Mem Inst Oswaldo Cruz 6 (2005): 671-677.
  2. Aisenberg G, Rolston KV, Safdar A. Bacteremia caused by Achromobacter and Alcaligenes species in 46 patients withcancer (1989–2003). Cancer 101 (2004): 2134-2140.
  3. Yabuuchi E, Yano I, Goto S, et al. Description of Achromobacter xylosoxidans Yabuuchi and Ohyama 1971. Int J Syst Bacteriol 24 (1974): 470-477.
  4. Mensah K, Philippon A, Richard C, et al. Susceptibility of Alcaligenes denitrificans subspecies xylosoxydans to beta-lactam antibiotics. Eur J Clin Microbiol Infect Dis 9 (1990): 405-409.
  5. Yabuuchi E, Yano I. Achromobacter gen. nov. and Achromobacter xylosoxidans (ex Yabuuchi and Ohyama 1971) nom. rev. International Journal of Systematic Bacteriology 31 (1981): 477-478.
  6. Cheron M, Abachin E, Guerot E, et al. Investigation ofhospital-acquired infections due to Alcaligenes denitrificans subsp. xylosoxydans by DNA restriction fragment length polymorphism. J Clin Microbiol 32 (1994): 1023-1026.
  7. Degand N, Ruimy R. Intérêts et limites actuelles du MALDI-TOF enmicrobiologie clinique. J Anti-infectieux 14 (2012): 159-167.
  8. Decre D, Arlet G, Danglot C, et al. A beta-lactamase-overproducing strain of Alcaligenes denitrificans subsp. xylosoxydans isolated from a case of meningitis." J Antimicrob Chemother 30 (1992): 769-779.
  9. Van Hal S, Stark D, Marriott D, et al. (2008). Achromobacter xylosoxidans subsp. xylosoxidans prosthetic aortic valve infective endocarditis and aortic root abscesses. J Med Microbiol 57 (1992): 525-527.
  10. Wintermeyer S M, Nahata M C. Alcaligenes xylosoxidans subsp xylosoxidans in children with chronic otorrhea. Otolaryngol Head Neck Surg 114 (1996): 332-334.
  11. Ahmed A A, Pineda R. Alcaligenes xylosoxidans contact lens-related keratitis. A case report and literature review. Eye Contact Lens 37 (2011): 386-389.
  12. Tena D, Gonzalez-Praetorius A, Perez-Balsalobre M, et al. Urinary tract infection due to Achromobacter xylosoxidans: report of 9 cases. Scand J Infect Dis 40 (2008): 84-87.
  13. D'Amato R F, Salemi M, Mathews A, et al. Achromobacter xylosoxidans (Alcaligenes xylosoxidans subsp. xylosoxidans) meningitis associated with a gunshot wound. J Clin Microbiol 26 (1988): 2425-2426.
  14. Fujioka M, Oka K, Kitamura R, et al. Alcaligenes xylosoxidans cholecystitis and meningitis acquired during bathing procedures in a burn unit: a case report. Ostomy Wound Manage 54 (2008): 48-53.
  15. Barton L L, Hoddy D M. Osteomyelitis due to Achromobacter xylosoxidan. Clin Infect Dis 17 (1993): 296-7. 151.
  16. Ozer K, Kankaya Y, Baris R, et al. Calcaneal osteomyelitdue to Achromobacter xylosoxidans: a case report. J Infect Chemother 18 (2012): 915-918.
  17. Swart J, Volker-Dieben H J, Reichert-Thoen J W. Alcaligenes xylosoxidans endophthalmitis 8 months after cataract extraction. Am J Ophthalmol 127 (1999): 345-346.
  18. Turkan Uygur, Ozden Turel, Sultan Kavuncuoglu, et al. Bacteremia due to Achromobacter xylosoxidans in neonates: clinical features and outcome. Elsevier Editora Ltda (2013).
  19. Turel O, Kavuncuoglu S, Hosaf E, et al. Bacteremia due to Achromobacter xylosoxidans in neonates: clinical features and outcome. Braz J Infect Dis 17 (2013): 450-454.

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