Transitional Cell Carcinoma: Impact of Life Style on Grading of Tumor

Author(s): Md. Mashiur Arefin, Homayra Tahseen Hossain

Background: Transitional cell carcinoma (TCC) is a common type of bladder cancer, predominantly affecting males exposed to certain chemical products and is strongly associated with tobacco consumption. Understanding the clinicopathological correlation and tumor grading in TCC is essential for effective management and prognosis.

Objective: This study is to examine the correlation between the impact of lifestyle and tumor grading in Transitional cell carcinoma (TCC).

Methods: A descriptive and cross-sectional retrospective study was conducted at Rajshahi Medical College Hospital, Bangladesh. A total of 144 cases of histologically confirmed TCC diagnosed between January 2019 and January 2021 were included. Patient records from the Department of Urology was analyzed, including demographic data, tobacco consumption, symptoms, and organ involvement. Tumour grading was assessed based on histopathological analysis.

Results: The majority of TCC cases were found in males (77.8%) compared to females (22.2%). Tobacco consumption was strongly associated with TCC, with a rate of 68.8%. Tumour grading revealed that 59% of cases were classified as low grades, while 41% were classified as high grades. High-grade TCC was more prevalent in males aged 50 to 69 years, particularly among smokers residing in rural areas engaged in cultivation.

Conclusion: This study provides insights into the clinicopathological characteristics of TCC, emphasizing the association with tobacco consumption and the predominance of high-grade tumours in specific demographic groups. These findings contribute to the understanding of TCC and may aid in the development of targeted prevention and treatment strategies for better patient outcomes. Further research is warranted to explore additional factors influencing TCC development and progression.