The Role of MALAT1 in Cancer

Author(s): Dake Chen, Tao Xu, Howard Hoyon Chang, Qi Song, Yu Zhu, Yan Han, Shubin Wang, Jian Chen

Long non-coding RNA (LncRNA) are involved in chromatin remodeling, transcriptional control, and post-transcriptional processing. The LncRNA, Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in metastasis for many cancers. In this review, we summarize recent findings of MALAT1 in lung cancer, colorectal cancer, breast cancer, cervical cancer, pancreatic cancer, hepatocellular cancer, gliomas, bladder cancer, esophageal cancer, stomach cancer, gall bladder cancer, nasopharyngeal cancer, osteosarcoma, ovarian cancer, prostate cancer, melanoma, tongue cancer, oral squamous cell carcinoma, and multiple myeloma.

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