The Clinical Significance and Diagnostic Value of Coagulation Function, Fecal Occult Blood in Combination with Tumor Markers in Colorectal Cancer

Author(s): Shengming Lai, Zhongchao Huang, Haiyan Huang, Yongsheng Huang, Yuanmei Zhang, Shuwei Ren

Background: A single tumor marker has limitations in the diagnosis of colorectal cancer. This study investigates the diagnostic value of the combined detection of coagulation function, fecal occult blood, and tumor markers in colorectal cancer. Methods: The total number of 262 patients with colorectal cancer confirmed in our hospital from January 2021 to September 2023 were selected as the observation group, and 266 patients with colorectal polyps diagnosed in the same period were selected as the control group. By comparing the differences in coagulation function, fecal occult blood, and tumor markers between the two groups, the indicators related to colorectal cancer were screened out, and the diagnostic value of single indicator detection and combined detection was discussed. Results: The differences in expression in prothrombin time (PT), thrombin time (TT), fibrinogen (FIB), carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), and Fecal occult blood (FOB) were statistically significant between the observation group and the control group (P<0.05). The maximum area under the receiver operating characteristic curve (ROC) curve for the combined detection of PT, FIB, FOB, CEA, and CA19-9 was 0.903. The combined detection of PT, FIB, CEA, CA19-9, and FOB was superior to the separate detection (P<0.05). Conclusion: This retrospective analysis reveals that combined testing is crucial in diagnosing colorectal cancer, as it can enhance the accuracy and specificity of colorectal tumor diagnosis compared to testing alone.