Safety of Chloroquine Associated with Azithromycin in Patients with Coronavirus Disease 2019

Author(s): Houda Nassih, Karima El Fakiri, Rabiy El Qadiry, Aicha Bourrahouat, Imane Ait Sab, Noureddine Rada, Ghizlane Draiss, Mohammed Bouskraoui

Objectives: To assess the safety of chloroquine and azithromycin in patients with coronavirus disease 2019.

Methods: We conducted a prospective study, including 19 adults infected with SARS-CoV-2 virus.

Results: The mean age was 33,6 years, and the sex ratio was 2:17. There were no severe toxicity cases. QTc prolongation was seen in two cases, and hypokalemia in one case. Treatment withdrawal was efficient in these three cases. Meanwhile, the majority of side effects were milder ones, mainly gastrointestinal and neuropsychiatric signs, responding well to symptomatic measures.

Conclusions: The association of chloroquine and azithromycin seems to be safe in patients with coronavirus disease 2019. However, caution and appropriate monitoring are necessary.

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