Renal Function of Sickle Cell Subjects in Edo State-Nigeria

Author(s): Airhomwanbor KO, Idehen IC, Okparaku SO, Dic-Ijewere EO, Ehimare RI, Osarobo E, Omolumen LE, Edetanlen GE

This study compares renal function of Sickle cell disease (SCD) patients and healthy subjects and investigates the influence of age and sex. The study involves 30 each of SCD patients and healthy subjects recruited within Edo State. Blood samples from patients and subjects who met the criteria for inclusion and gave consent were evaluated for kidney function as well as electrolytes profile. The results were compared using “t test” and ANOVA where appropriate with p<0.05 considered significance. The results showed significant higher (p<0.05) bicarbonate and creatinine levels in SCD patients compared to healthy subjects. However, there were non-significant difference (p>0.05) in Na+, Cl-, K+ and urea levels between the groups. On the impact of sex, K+ and Creatinine levels were significantly different (p<0.05) between the groups. On age impact, there was significant difference (p<0.05) in K+, bicarbonate and creatinine in the different age groups between SCD and healthy subjects. The findings of this study suggest the need for routine evaluation of kidney function to help SCD patients to avert the inherent danger of kidney diseases and destruction.

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