Impact of Maternal Ultra-Processed Food Consumption and Preterm Birth on the Development of Metabolic Disorders in Offspring

Author(s): Gauri Gurumurthy, Devendra K. Agrawal*

This review examines the growing concern regarding the relationship between maternal ultra-processed food (UPF) consumption, preterm birth, and the subsequent development of metabolic disorders in offspring. Ultra-processed foods have become increasingly prevalent in global diets, coinciding with rising rates of metabolic diseases. Concurrently, preterm birth remains a significant public health concern affecting 5-18% of births worldwide. Here, we critically reviewed the current evidence regarding how maternal UPF consumption affects fetal development and how preterm birth disrupts metabolic programming. Furthermore, the information is presented on the potential synergistic effects when both factors are present. The mechanisms underlying these associations, including fetal malnutrition, inflammation, and hormonal dysregulation, are analyzed. Research suggests that maternal UPF consumption and preterm birth independently contribute to altered metabolic health in offspring, with potential compounding effects when both factors are present. This review highlights the public health implications of these findings and identifies areas requiring further research to better understand the complex interplay between maternal diet, preterm birth, and long-term metabolic health outcomes in offspring.