Gut Microbiota Signature in Atopics Dermatitis: Experience gained at the “L. Sacco” University Hospital, in Milan, Italy

Author(s): Rimoldi SG, Caron L, Alvaro A, Comandatore F, Curreli D, Salari F, Pagani C, Lombardi A, Micheli V, Tamoni A, Iemoli E, Gismondo MG

Literature have suggested that gut microbiota is a key factor in the development and have a role in the clinical progress of atopic dermatitis (AD) affected patients. We aimed in the current study to better investigate the gut microbiota in AD before and after probiotics subministration. Faecal samples collected from 63 subjects (48 AD patients that completed probiotic assumption and 15 (HC)), were microbiologically investigated with a 16S rRNA amplicon metagenomics analysis. The microbiota results indicated that microbial diversity is lower in AD patients than healthy controls, according with Chao Index. The relative abundance showed the presence at the class level, of Bacilli, less abundant in atopic dermatitis with gastroenteritis (AD_GE) in comparison to the other categories (pvalue 0.052), while Deltaproteobacteria and Erysipelotrichi were more abundant in AD_worsened than in the other groups. At family level, Porphyromonadaceae were more abundant in AD_GE than AD or AD_worsened (pvalue 0.0044), Ruminococcaceae were less abundant in AD_GE than the other categories and Gracilibacteraceae were significantly less abundant in AD than Control patients and more abundant in AD_worsened than AD. In future a larger cohort is needed to support our data.

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