External Validation of Models to Predict Unsuccessful Endometrial Ablation: A Retrospective Study

Author(s): Stevens Kelly Yvonne Roger, Muller Iris, Houterman Saskia, Weyers Steven, Schoot Benedictus

Study Objective

External validation of our previously presented and locally established prediction models to help counsel patients for failure of endometrial ablation (EA) or surgical re-intervention within 2 years after EA, called ‘Failure model’ and ‘Re-intervention model’ respectively.


Retrospective external validation study, minimal follow-up time of 2 years.


Two non-academic teaching hospitals in the Netherlands.


Pre-menopausal women (18+) who had undergone EA for abnormal uterine bleeding problems between January 2010 and November 2012. A total of 329 patients were eligible for analysis.


Interventions used for EA were Novasure (Hologic, Marlborough, Massachusetts, US) and ThermaChoice III (Ethicon, Sommerville, US).

Measurements and Main Results

The Area Under the Receiver Operating characteristics Curve (AUROC) for the outcome parameter of failure within 2 years after EA was 0.59 (95% CI 0.53 – 0.65). Variables in this model were dysmenorrhea, age, parity ≥5 and preoperative menorrhagia. The Hosmer-Lemeshow test showed no significant difference between the observed and predicted outcome. (Chi-square: 4.62, P-value: .80) The AUROC for the outcome parameter surgical re-intervention within 2 years was 0.62 (95% CI 0.53 – 0.70) Variables in this model were dysmenorrhea, age, menstrual duration>7 days, parity ≥5 and a previous caesarean section. The Hosm

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