Evaluation of Regional Left and Right Ventricular Function in Patients with Ostium-Secundum Atrial Septal Defect Using Speckle Tracking Echocardiography

Author(s): Toan Pham, Guillermo Bracamontes-Castelo, Neftali Eduardo Antonio-Villa, Leonel Avendaño-Pérez, Karina del Valle Zamora, Candace Keirns, Enrique Berrios-Barcenas, Nilda Espinola-Zaval

The aim of this study was to provide evidence of abnormalities of right ventricular (RV) and left ventricular (LV) function using speckle tracking echocardiography (STE) in adults with ostium secundum-atrial septal defect (OS-ASD) and pulmonary hypertension (PH).

Sixty-three adult patients with OS-ASD were enrolled. Control group (n=10) with mean pulmonary arterial pressure (MPAP) ≤25 mmHg. Three PH groups were divided based on pulmonary artery systolic pressure (PASP): mild (n=18), moderate (n=24) and severe (n=11). RV free wall strain (RVFWS) and LV global longitudinal strain (LVGLS) were measured.

RVFWS and RV fractional area change were significantly lower in the severe PH group. No difference was found in LVGLS among groups. The moderate PH group had significantly higher right atrial (RA) volume and RV impaired relaxation. RVFWS had a positive correlation with PASP and MPAP.

STE is a valuable non-invasive technique to assess RV and LV systolic function in patients with OS-ASD.

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