Evaluation of Polyherbal Film- Forming Gel for Treatment of Fungal Infection

Author(s): Shefali Srivastava, Dr. Varsha Deva

Aim of study was the evaluation of a topical film-forming gel containing polyherbal extracts for treatment of fungal infection. The evaluation of anti-fungal potential was done using Wistar rats. Four hours before to the start of the study, the dorsal side of the skin was shaved with an electric clipper, and any leftover hair was removed by applying Veet cream for five minutes. The region was then washed with alcohol and wiped with moist cotton. Total 18 healthy female Wistar albino rats weighing between 200g-250g were infected and split into six groups: group 1 (normal control), group 2 (disease control), group 3 (test drug), group 4 (standard drug), group 5 (optimal formulation), and group 6 (blank). Following confirmation of the fungal growth, the drug's application began. Rats with the infection received treatment for 14 days. In results, the anti-fungal potential was observed and found significant at day 1, day 3, day 7, day 10 and day 14 when compared with the blank/placebo. It concluded that polyherbal film forming gel is effective as anti-fungal which might destroy the growth of fungus stains on Wistar rats. It suggests, to determine the mode of action of anti-fungal potential of film forming gel.