Eosinophilic Esophagitis induced by semaglutide use: A case report

Author(s): Pérez-Macías JP, Wade-Isidro ME, Treviño-Ayala M, De León-Rosas DA

We report the case of a 46-year-old male patient undergoing treatment with a GLP-1 receptor agonist (semaglutide) for six months, who developed progressive dysphagia to solids and a retrosternal foreign body sensation. An upper endoscopy revealed impacted food at 40 cm from the dental arch, which was successfully advanced into the stomach. At the same location, three small fibrin-covered ulcers were identified. Histopathological analysis of esophageal biopsies confirmed the diagnosis of eosinophilic esophagitis. Follow-up evaluations at one and three months showed the patient remained asymptomatic, adherent to an allergen-free restrictive diet and proton pump inhibitor therapy, without resuming semaglutide and without requiring corticosteroid treatment. This case highlights the importance of recognizing potential adverse effects of pharmacological agents, even when they are rare or scarcely reported in the literature. Such awareness may improve patient outcomes and provide valuable insight for clinicians managing similar presentations.