Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease?

Author(s): Alexis Lacout, Christian Perronne

This paper discusses the case of a 40-year-old male patient presenting with a "polymorphic persistent syndrome after a possible tick bite" (SPPT), a syndrome officially recognized by the French High Authority for Health (HAS). Anti-infection protocols were implemented, gradually improving the patient's clinical condition until complete remission was achieved. Each time flubendazole was taken, it was accompanied by severe symptoms - not suggestive of adverse reactions but of a Jarisch-Herxheimer reaction. Each administration of flubendazole was followed by a period of remission of symptoms.