Cerebro-Costo-Mandibular Syndrome in a COVID-19 Positive Neonate: Clinical and Radiological Findings
Author(s): Belekar Neelam, Sarawade Sudhir
Cerebro-costo-mandibular syndrome (CCMS) is also known as rib-gap defect with micrognathia syndrome. It is a condition comprising a constellation of mandibular hypoplasia presenting as micrognathia, abnormalities of roof of mouth (palate) and posterior rib defects as its basic features. Other signs and symptoms may include microcephaly, spina bifida. These anatomical problems predispose these patients to respiratory difficulties associated with upper airway obstruction, reduced thoracic capacity and scoliosis. We describe a sporadic case of a full-term female neonate born to a COVID-19 infected mother in third trimester with features of micrognathia, high arched palate with palatal hypoplasia, cervical spina bifida along with preauricular skin tag and congenital heart disease, presenting as respiratory distress at birth Cerebro-costo-mandibular Syndrome (CCMS) and with a good short term outcome.