Biosynthesis of Silver Nanoparticles from Microsorum Punctatum (L.) Copel Fronds Extract and an In-vitro Anti-Inflammation Study

Author(s): Philippe Belle Ebanda Kedi, Chick Christian Nanga, Awawou Paboudam Gbambie, Vandi Deli, Francois Eya’ane Meva, Hamza Elsayed Ahmed Mohamed, Agnes Antoinette Ntoumba, Moise Henri Julien Nko&rs

The present study reports a cost-effective and eco-friendly silver nanoparticles synthesis using Microsorum punctatum frond extract as a new solution in the development of therapeutic strategies against inflammation. Egg albumin denaturation model was used to ascertain the anti-inflammatory potential of the biosynthesized silver nanoparticles. Plasmon resonance surface peaked at 440 nm and particles interface were coated with organics. X-ray diffraction pattern showed nanocrystallite nature of 20.05 nm and 39.46 nm size for silver and silver chloride, respectively while the hydrodynamic diameter size was found to be 29.7 ± 9.7 nm. Elemental mapping reveals particles consisting of silver, chloride or carbon among main elements. Highly aggregated and polydispersed spherical silver grain of 10-45 nm size were depicted with electron microscopy. Biosynthesized nanoparticles significantly inhibited thermally induced albumin denaturation indicating their capability to control protein denaturation involved in the inflammatory process thus, plausibly account for the pharmaceutical use of the plant.

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