A Proprietary Dual Polyphenolic Ingredient for Endurance, Muscle Performance, and Muscle Protection in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Study

Author(s): Shankaranarayanan Jeyakodi, Arunkanth Krishnakumar, Mohan Muttanahally Eraiah, Jestin V. Thomas, Lincy Benzy Joshua

Background and objectives: The potential of herbal substances can be harnessed to improve endurance, muscle performance, and muscle protection in addition to physical activity and diet. The present study aimed to evaluate the efficacy of Gremin^®, a proprietary dual polyphenolic ingredient (PDPI) in enhancing endurance, muscle performance, and muscle protection in healthy adults compared to placebo.

Methods: Sixty healthy adults took PDPI and a placebo for 14 days at a once-daily dose of 500 mg. Endurance measured by physical performance tests, VO2 max, and the six-minute walk test, isometric muscle strength assessed with a handheld dynamometer, and fatigue evaluated using the Multidimensional Fatigue Inventory (MFI) questionnaire were considered the primary objectives. Secondary objectives included muscle recovery (based on the levels of lactate dehydrogenase and C-reactive protein), muscle mass and lean body mass measured using dual-energy X-ray absorptiometry (DEXA) scans, and the safety assessments (blood tests) including adverse events.

Results: PDPI showed significantly enhanced endurance evidenced by the results of the 6-minute walk test, improved muscle strength as seen from the results of the isometric muscle strength study, and reduced fatigue as assessed using the MFI questionnaire compared to the placebo at the end of the study. DEXA scan results showed PDPI significantly increased the lean body mass and fat-free mass compared to its baseline. Throughout the study, PDPI was well-tolerated without any clinically notable adverse events or abnormal blood test results.

Conclusion: The present clinical evidence highlights the effectiveness of Gremin^® in significantly enhancing endurance, improving muscle performance, and providing robust muscle protection, making it a potential supplement for athletes and active individuals looking to elevate their physical performance and recovery. However, long-term clinical study in healthy subjects may be warranted to confirm the long-term safety and effectiveness of Gremin^®.