The Differential Effects of Radiofrequency Ablation and Hepatic Resection on Serum IL-10 Level in Patients with Liver Cancer

Author(s): Nona Janikashvili, Nino Kikodze, Manana Iobadze, Ketevan Mazmishvili, Natela Paksashvili, Ia Pantsulaia, Ani Gvajaia, Malkhaz Mizandari, Tinatin Chikovani

Liver cancer is a rapidly lethal cancer and is on the rise worldwide. Surgery is a gold standard treatment for primary liver cancer and liver metastases, however, non-surgical locoregional treatment options are of increasing clinical interest when tumor size, number and sites permit. Previous studies underline immunomodulatory effects of radiofrequency ablation (RFA) in patients with liver cancer. RFA seems to promote effector immune cell frequencies and diminishing immunosuppressive leukocytes. Nevertheless its impact on extracellular tumor matrix is practically uncovered. Herein we report on the differential effects of RFA and surgical liver resection on serum level of anti-inflammatory marker IL-10 in patients with hepatic cancer.